Despite its large size, Rome is a relatively safe city and does not register a high crime rate. However, like any big city, there are some areas which are more at risk of crime (theft in particular) than others. Areas to be more vigilant are Stazione Termini (the city’s main train station), and some crowded subway cars and busses (Like the famous line 64, which takes tourists to the Vatican). There is no need to panic, simply follow the normal rules of caution as you would in any city, including your own.